【谷氨□胺庆大霉素对大鼠急性胰腺炎细菌易位的预防作用】马克威.pdf

摘要胺对急性胰腺炎发生后胰腺感染的预防作用及其机理,将185只大鼠分成4组:1组:假手术组(N=30)2组:实验组(N=50),制成急性胰腺炎模型.3组:选择性消化道去污染治疗组(N=52),制成急性胰腺炎模型后6小时,口服庆大莓素400u/100g/d.4组:谷氨酰胺治疗组(n=53),制成急性胰腺炎模型后6小时开始口服谷氨酰胺0/100g/d.另用6只正常大鼠做空白对照。大鼠分别于术后24、48、72、96及144小时处死,取肠系膜淋巴结、胰腺、肝、脾、门静脉血及盲肠内容物作细菌培养,菌种鉴定和菌落计数。手术全过程均严格按着无菌操作进行。

nusiIa Toinvestigatetheeffects sofselectivedigest decontamination(SDD)treatmentandenteralGLN pancreaticinfectioninthemodelofacutepancreatitis(AP)and their mechanism,185 Wister rats were.divided into 4groups:1 Sham group(n=30),2Experimental group(n=50)simpleAPmode1.

throughintestinalmucosatoMLNandpancreas.Ecoli wasthe principalgram.negativeorganismisolatedin infectedorgans1 L-GLNmaintainedtheintestinal morphology and gut barrier function,and early pancreaticinfectionafterAPcanbereducedbySDD regimen orbyoralGLN.