【抗CD4抗体对CD4-45RA+和CD4-45RO+T细胞的效应及IL-4对该亚群IL-4产生细胞的作用】王江滨.pdf
The effect of anti-CD4 on CD4,45RA+VS.CD4,45R0+T cells and the role of IL-4 on IL-4-producing cells inthe two subpopulations
Cross-linking CD3-CD3,CD4-CD4orCD3-CD4mayinducea greater elevation of[Ca+]inCD4,45RO+thaninCD4,45RA+Tcels Enhanced Ca2+signal in CD4,45RO+T cells may be inhibited by anti-CD4 Addition of a calcium-ionophore overcomes the inhibitory effect of anti-CD4ontheproliferationresponseofCD4,45RO+Tcel
Introduction anti-CD4antibodieshavebeenextensivelyusedinanimalmodelfor treatmentofseveralautoimmunediseaseandforthepreventionofgraft rejection [Shizuru,1987][ Wofsy,1987][ Ranges,1985][ Shizuru,1988] Recently,anumberofpilotstudieswereinitiatedtotreatpatientswith autoimmunediseaseincludingmultiplescl