【氧化修饰低密度脂蛋白中的溶血卵磷脂对内皮功能的损伤】陈立.pdf
ACKNOWLEDGEMENTS Iwant to express my sinceregratitude and appreciate toDr.Yang Hanyi,Dr.RickyY.K.Man and Dr.Patrick C.Choy,my supervisor,not onlyfor their excellent guidance and encouragement,but alsofor their model example of a perfect scientist,i.e.
1.BiologyofoxidisedLDL in different experiment condition.Oxidativemodificationoflowdensitylipoproteininnormal and hyperlipidemicpatients3.Impairment ofendothelium-dependentrelaxation by oxidativelymodified LDLisgender-dependent inhyperlipidemic patients.
Results: Oxidised LDLdisplayed higher amount of TBARS than nativeLDL.The amounts of TBARS in LDL modified at 20°C and 37°C were similar.Oxidised LDLincreaseelectrophoreticmobility.TheincreaseinmobilitywasgreaterinLDI oxidised at 37°C than in LDL oxidised at 20°C.